Year: 1999
Type: article
Abstract: Rats were given repeated injections of 10 mg/kg of morphine and were then left undisturbed for 24-25 days before their brains were processed for Golgi-Cox staining. Prior exposure to morphine decreased the complexity of dendritic branching and the number of dendritic spines on medium spiny neurons in the shell of the nucleus accumbens and on pyramidal cells in the prefrontal and parietal cortex. It is suggested that some of the long-term behavioral consequences of repeated exposure to morphine may be due to its ability to reorganize patterns of synaptic connectivity in the forebrain.
Source: Synapse
Authors: Terry E. Robinson, Bryan Kolb
Institutions: University of Michigan, University of Lethbridge
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1990996190