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Immune Responses Contribute to Depression, Fatigue, and Pain in Blood and Marrow Transplant Recipients

Year: 2012

Type: article

Abstract: Depression, fatigue, and pain are prevalent and distressing quality of life concerns for individuals recovering from blood and marrow transplantation (BMT). Recent research in other cancer populations suggests inflammatory cytokines can activate central nervous system pathways, evoking adverse behavioral responses including depressed mood, fatigue, and pain. We hypothesized that immune responses also contribute to these symptoms among BMT recipients. Allogeneic (n = 24) and autologous (n = 68) transplant recipients completed well-validated measures of depressive symptoms, fatigue, and pain prior to transplant and 30, 100, and 200 days post-transplant.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2011.12.215