P1-S2.54 Repeat Gonococcal and chalymadial infections in a cohort of men who have sex with men in India
Year: 2011
Type: article
Study design: Observational Study
Abstract: Background Men who have sex with men (MSM) are found to be at increased risk for many sexually transmitted infections (STI). Among the STIs, most common are bacterial STIs such asNeisseria gonorrhoea(NG) andChlamydia trachomatis(CT). In the present study we analysed determinants of repeat gonococcal and chlymadial infections among the cohort of high-risk MSM. Methods Between 2008 to 2009, 512 MSM attending STI clinics in four clinics of two cities (Mumbai and Hyderabad) of India were recruited and followed for 3 months. First catch urine, rectal swabs, Pharyngeal swabs were collected in all visits and tested for NG and CT by Gen-Probe APTIMA Combo II assay and Roche PCR (Pharyngeal swabs positive by Roche Amplicor and 16s RNA NG PCR were considered). Presumptive treatment for gonorrhoea and chlamydia at the baseline visit and syndromic STI management at all subsequent visits was provided during the study period. Re-infection was defined as a positive test result occurring after 30 days and above after an initial positive result until the last follow-up. Results Of 417 MSMs recruited during 2008−2009, 454 made at least on fallow-up visit. Three hundred and fifteen were NG infected and 138 were CT infected. 41 (9%) NG and 7 (1.5%) CT re-infections were observed during the follow-up visits see Abstract P1-S2.54 Table 1. Past history of STI (as reported by the participants) (OR=2.82, p=0.00) and diagnosis of any STI by Physician (OR=2.24, p=0.05) were significantly associated factors with re-infection. Conclusions Cumulative incidence of repeat gonococcal infections among MSMs highlight the need of a routine STI screening, prevention counselling, promoting use of consistent condom, laboratory screening and prompt treatment of patients at high risk. These efforts maximally help in avoiding recurrent NG/CT re-infection among high risk MSMs and there partners. Abstract P1-S2.54 Table 1 Re-infection frequency among cohort of men having sex with men in India Visits Visit 1 Visit 2 Visit 3 Visit 4 Total NG-Re-infection No re-infection/ Negatives 512 435 342 232 1521 Re-infected (31 to 292 days) 0 19 13 9 41 Total 512 454 355 241 1562 CT-Re-infection No re-infection/Negatives 512 451 352 240 1555 Re-infected (31 to 291 days) 0 3 3 1 7 Total 512 454 355 241 1562
Source: Sexually Transmitted Infections
Authors: G R Deshpande, A R Risbud, P Narayanan, P parimi, A Das
Institution: National AIDS Research Institute
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1991088688