Work

Nuclear function of Alus

Year: 2014

Type: article

Abstract: Alus are transposable elements belonging to the short interspersed element family. They occupy over 10% of human genome and have been spreading through genomes over the past 65 million years. In the past, they were considered junk DNA with little function that took up genome volumes. Today, Alus and other transposable elements emerge to be key players in cellular function, including genomic activities, gene expression regulations, and evolution. Here we summarize the current understanding of Alu function in genome and gene expression regulation in human cell nuclei.

Source: Nucleus

DOI: 10.4161/nucl.28005

Authors: Chen Wang, Sui Huang

Institution: Northwestern University

Language: Hebrew

Topic: Chromosomal and Genetic Variations

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $1,993

Funders: National Institutes of Health, National Institute of General Medical Sciences