Work

Application of Catalytic Dynamic Resolution of N-Boc-2-lithiopiperidine to the Asymmetric Synthesis of 2-Aryl and 2-Vinyl Piperidines

Year: 2010

Type: article

Abstract: The highly enantioselective synthesis of 2-aryl- and 2-vinyl-piperidines has been accomplished through a catalytic dynamic resolution (CDR) of N-Boc-2-lithiopiperidine. The method has been applied to the synthesis of both enantiomers of the tobacco alkaloid anabasine.

Source: Organic Letters

DOI: 10.1021/ol102682r

Authors: Timothy K. Beng, Robert E. Gawley

Institution: University of Arkansas at Fayetteville

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: U.S. Public Health Service, National Center for Research Resources

Awards: Center for Protein Structure and Function, G7772536260