Work

Cyanide Antidotes for Mass Casualties: Water-Soluble Salts of the Dithiane (Sulfanegen) from 3-Mercaptopyruvate for Intramuscular Administration

Year: 2013

Type: article

Abstract: Current cyanide antidotes are administered by IV infusion, which is suboptimal for mass casualties. Therefore, in a cyanide disaster, intramuscular (IM) injectable antidotes would be more appropriate. We report the discovery of the highly water-soluble sulfanegen triethanolamine as a promising lead for development as an IM injectable cyanide antidote.

Source: Journal of Medicinal Chemistry

DOI: 10.1021/jm301633x

Authors: Steven E. Patterson, Alexandre R. Monteil, Jonathan F. Cohen, Daune L. Crankshaw, Robert Vince, Herbert T. Nagasawa

Institutions: University of Minnesota, United States Department of Veterans Affairs, Minneapolis VA Medical Center

Language: English

Topic: Cassava research and cyanide

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Neurological Disorders and Stroke