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The heme–p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis

Year: 2014
Type: article
Abstract: Recently, we reported that heme binds to tumor suppressor p53 protein (TP53, best known as p53) and promotes its nuclear export and cytosolic degradation, whereas iron chelation stabilizes p53 protein and suppresses tumors in a p53-dependent manner. This not only provides mechanistic insights into tumorigenesis associated with iron excess, but also helps guide the administration of chemotherapy based on iron deprivation in the clinic.
DOI: 10.4161/23723548.2014.965642
Authors: Jia Shen, Xiangpeng Sheng, ZeNan Chang, Qian Wu, Dong Xie, Fudi Wang, Ronggui Hu
Institutions: University of California, Los Angeles, Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, California Institute of Technology, Shanghai Institutes for Biological Sciences, Zhejiang University
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $1,590
OpenAlex ID: W1991508305
FWCI: 0.482
Cites: 10
Cited by: 13
Related to: 10