Work

Temperature-Activated Nucleic Acid Nanostructures

Year: 2013

Type: article

Abstract: DNA and poly(N-isopropylacrylamide) are co-assembled onto gold nanoparticles. The DNA sequences can be reversibly exposed or hidden from the polymer surface in response to temperature cues, thereby translating the temperature trigger to the on-off switching of the surface chemistry and function. When exposed by heating (∼30 °C), the DNA rapidly hybridizes to complementary strands, and chain-end biotin groups become readily accessible, while at lower temperatures these activities are largely blocked.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja408465t

Authors: Ke Zhang, Xiao Zhu, Fei Jia, Evelyn Auyeung, Chad A. Mirkin

Institutions: Northeastern University, Texas Advanced Computing Center, The University of Texas at Austin, Northwestern University, International Institute for Nanotechnology

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Cancer Institute

Award: G1745892387