Work

Protein‐Engineered Biomaterials to Generate Human Skeletal Muscle Mimics

Year: 2012

Type: article

Abstract: Protein-engineered biomaterials are designed to enable culture and differentiation of human myoblasts (isolated from skeletal muscle biopsies) into functionally contractile myotubes ex vivo. Individual myoblasts align with microtopographical features (white dashed lines), fuse to form myotubes with several nuclei (blue), and form sarcomeric structures (α-actinin, green) that enable electrical pacing of contractions.

Source: Advanced Healthcare Materials

DOI: 10.1002/adhm.201200195

Authors: Debanti Sengupta, Penney M. Gilbert, Kyle J. Johnson, Helen M. Blau, Sarah C. Heilshorn

Institutions: Stanford University, Stanford Medicine

Language: English

Topic: Tissue Engineering and Regenerative Medicine

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases