Work

Lack of association of HLA class I genes and TNF α‐308 polymorphism in toluene diisocyanate‐induced asthma

Year: 2003

Type: article

Abstract: BACKGROUND: Toluene diisocyanate (TDI)-induced asthma is a common cause of occupational asthma and it affects 5-15% of the exposed population suggesting an underlying genetic susceptibility. METHODS: To investigate the role of genetic factors in the development of TDI-induced asthma, we analyzed the distribution of human leukocyte antigen (HLA) class I genes and of tumor necrosis factor (TNF)-alpha A-308G polymorphism in 142 patients with TDI-induced asthma and in 50 asymptomatic exposed subjects. RESULTS: Neither the distribution of HLA class I antigens nor the distribution of TNF-alpha A-308G polymorphism was different between patients with TDI-induced asthma and asymptomatic exposed subjects. CONCLUSIONS: These results suggest that HLA class I antigens and TNF-alpha A-308G are not associated with susceptibility or resistance to the development of TDI-induced asthma.

Source: Allergy

DOI: 10.1046/j.1398-9995.2003.00352.x

Authors: B. Beghé, M. Padoan, C. T. Moss, S. J. Barton, J. W. Holloway, S. T. Holgate, W. M. Howell, C. E. Mapp

Institutions: University of Padua, University Hospital Southampton NHS Foundation Trust, University of Southampton, University of Ferrara

Language: English

Topic: Occupational exposure and asthma

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1991719776

FWCI: 4.363

Cites: 9

Cited by: 53

Related to: 10