Work

Thiopeptide Antibiotics: Retrospective and Recent Advances

Year: 2014

Type: review

Abstract: Thiopeptides, or thiazolyl peptides, are a relatively new family of antibiotics that already counts with more than one hundred different entities. Although they are mainly isolated from soil bacteria, during the last decade, new members have been isolated from marine samples. Far from being limited to their innate antibacterial activity, thiopeptides have been found to possess a wide range of biological properties, including anticancer, antiplasmodial, immunosuppressive, etc. In spite of their ribosomal origin, these highly posttranslationally processed peptides have posed a fascinating synthetic challenge, prompting the development of various methodologies and strategies. Regardless of their limited solubility, intensive investigations are bringing thiopeptide derivatives closer to the clinic, where they are likely to show their veritable therapeutic potential.

Source: Marine Drugs

DOI: 10.3390/md12010317

Authors: Xavier Just-Baringo, Fernando Albericio, Mercedes Álvarez

Institutions: Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, Institute for Research in Biomedicine, Parc Científic de Barcelona, Universitat de Barcelona, University of KwaZulu-Natal

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499