Work

Altered energy metabolism in cancer

Year: 2013

Type: review

Abstract: The early observations by Dr Otto Warburg revealed that fundamentally metabolic differences exist between malignant tumor cells and adjacent normal cells. Many studies have further reported the relationship between altered cellular metabolism and therapeutic outcomes. These observations suggest that targeting the peculiar metabolic pathways in cancer might be an effective strategy for cancer therapy. In recent years, investigations have accelerated into how altered cellular metabolism promotes tumor survival and growth. This review highlights the current concepts of altered metabolism in cancer and the molecular targets involved in glycolysis, mitochondria and glutamine metabolism and discusses future perspective of cellular metabolism-based cancer treatment.

Source: Cancer Biology & Therapy

DOI: 10.4161/cbt.22958

Authors: Yi Zhang, Jin-Ming Yang

Institutions: Soochow University, Pennsylvania State University, Penn State Cancer Institute

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Natural Science Foundation of China, Priority Academic Program Development of Jiangsu Higher Education Institutions, National Cancer Institute