Work

Getting in Shape: Controlling Peptide Bioactivity and Bioavailability Using Conformational Constraints

Year: 2012

Type: review

Abstract: Chemical biologists commonly seek out correlations between the physicochemical properties of molecules and their behavior in biological systems. However, a new paradigm is emerging for peptides in which conformation is recognized as the primary determinant of bioactivity and bioavailability. This review highlights an emerging body of work that directly addresses how a peptide's conformation controls its biological effects, cell penetration, and intestinal absorption. Based on this work, the dream of mimicking the potency and bioavailability of natural product peptides is getting closer to reality.

Source: ACS Chemical Biology

DOI: 10.1021/cb300515u

Authors: Jonathan E. Bock, Jason Gavenonis, Joshua A. Kritzer

Institution: Tufts University

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Award: Training in Education and Critical Research Skills