JCV and BKV prevalence in people infected with HIV-1
Year: 2008
Type: article
Study design: Observational Study
Abstract: Human pathogenic viruses of the polyoma type were discovered only in the 70s of the 20th century. So far seroepidemiologic researches concerning these infections have been carried out on small groups and probably are not representative of the entire of population. They showed a past polyomaviruses infection in 35–85% people in a healthy population. In two cases: JSV and BKV reactivation plays a role in a development of diseases in people with impaired immunological response, e.g. HIV infection history. The aim of the study was to examine the frequency of prevalence of JCV and BKV in various body fluids and pathogenicity connected with these viruses in patients infected with HIV-1. The tests included 108 people of both sexes, in whom HIV-1 infection was diagnosed. JCV/BKV infection was diagnosed in 27 (25%) HIV-1 infected patients, where JCV constituted 18 (16.7%) cases and 9 (8.3%) BKV. The infections were proven on the basis of a presence of virus genetic material in urine. In none of the patients was JCV and BKV detected in blood and cerebrospinal fluid. In the patient group with TCD4 lymphocyte count < 200 cell/μL JCV DNA was detected in urine in 5 (11.4%), and BKV in 7 (15.9%) cases, in turn in the group of people with neurological conditions JCV in 3 (15%) and BKV also in 3 (15%) cases, (together in 6 (40%) people). Among the tested people with lymphocyte TCD4 lymphocyte count > 500 cell/μL JCV DNA was detected in urine in 9 (20.5%) cases and BKV DNA in 1 (2,3%) case.
Source: HIV & AIDS Review
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1991845068