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Osteocyte RANKL: New insights into the control of bone remodeling

Year: 2012
Type: review
Abstract: The idea that osteoblasts, or their progenitors, support osteoclast formation by expressing the cytokine receptor activator of NFkB ligand (RANKL) is a widely held tenet of skeletal biology. Two recent studies provide evidence that osteocytes, and not osteoblasts or their progenitors, are the major source of RANKL driving osteoclast formation in cancellous bone. The goal of this review is to highlight the results of these new studies and discuss their implications for our understanding of bone remodeling.
DOI: 10.1002/jbmr.1547
Language: English
Open Access status: bronze
Funders: U.S. Department of Veterans Affairs, National Institutes of Health, Translational Research Institute, University of Arkansas for Medical Sciences, National Institute on Aging, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Center for Research Resources
Awards: G1971084046, G247990007, Arkansas Center for Clinical and Translational Research, G739146318, G806251664, Molecular and Cellular Mechanisms of Osteoporosis, G9000295432, Osteocyte Control of Bone Remodeling
OpenAlex ID: W1991882891
FWCI: 2.741
Cites: 76
Cited by: 287
Related to: 10