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Effect of a new non‐steroidal anti‐inflammatory drug, nitroflurbiprofen, on the expression of inducible nitric oxide synthase in rat neutrophils

Year: 1995

Type: article

Abstract: The effects of a non-steroidal anti-inflammatory drug, flurbiprofen, and its nitro-derivative, nitroflurbiprofen, on inducible nitric oxide synthase in rat neutrophils were examined. Nitroflurbiprofen was shown to inhibit nitric oxide synthase induction caused by lipopolysaccharide administration, while flurbiprofen had no effect on nitric oxide synthase induction. This inhibitory action may be ascribed to nitric oxide released from nitroflurbiprofen.

Source: British Journal of Pharmacology

DOI: 10.1111/j.1476-5381.1995.tb15867.x

Authors: S. Mariotto, L. Cuzzolin, A. Adami, P. DEL Soldato, H. Suzuki, G. Benoni

Institution: University of Verona

Language: English

Topic: Inflammatory mediators and NSAID effects

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1991996044

FWCI: 2.385

Cites: 8

Cited by: 31

Related to: 10