Work

Investigating Mithramycin Deoxysugar Biosynthesis: Enzymatic Total Synthesis of TDP‐ D ‐Olivose

Year: 2011

Type: article

Abstract: Mix'n'match: Enzymatic total synthesis of TDP-D-olivose was achieved, starting from TDP-4-keto-6-deoxy-D-glucose, by combining three pathway enzymes with one cofactor-regenerating enzyme. The results also revealed that MtmC is a bifunctional enzyme that can perform a 4-ketoreduction necessary for D-olivose biosynthesis besides the previously found C-methyltransfer for D-mycarose biosynthesis.

Source: ChemBioChem

DOI: 10.1002/cbic.201100540

Authors: Guojun Wang, Madan K. Kharel, Pallab Pahari, Jürgen Rohr

Institutions: University of Kentucky, Midway University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute

Awards: G2143565781, Novel aureolic acid type antitumor agents