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CMVpp65-Specific T Cells Generated from Naïve T Cell Populations Recognize Atypical but Not Canonical Epitopes and May Be Protective In Vivo

Year: 2015
Type: article
Abstract: Adoptive transfer of CMVpp65-specific T-cells (cCTL) from CMV-seropositive (CMVpos) donors effectively restores antiviral-immunity after stem cell transplantation. However, the naïve T-cells in cord blood(CB) and adult CMV-seronegative(CMVneg) donors require different culture systems to generate cCTL. With a novel GMP-applicable protocol we have reliably generated cCTL from CB and CMVnegs and found that of >20 T-cell lines, all recognized atypical epitopes of pp65. HLA-A2+ cCTL derived from naive T-cells recognized novel pp65 epitopes (e.g.
DOI: 10.1016/j.bbmt.2014.11.049
Authors: Patrick J. Hanley, Jan Melenhorst, Sarah Nikiforow, Phillip Scheinberg, Russell Cruz, Robert A. Krance, Kathryn Leung, Caridad Martinez, Helen E. Heslop, Cliona M. Rooney, A. John Barrett, Elizabeth J. Shpall, Catherine M. Bollard
Institutions: Children's National, National Institutes of Health, National Heart, Lung, and Blood Institute, Harvard University, Dana-Farber Cancer Institute, Dana-Farber/Harvard Cancer Center, Beneficência Portuguesa de São Paulo, Houston Methodist, Baylor College of Medicine, Texas Children's Hospital, The University of Texas MD Anderson Cancer Center
Language: English
Subfield: Epidemiology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W1992230105
FWCI:
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