Year: 2013
Type: review
Abstract: Antiretroviral therapy can inhibit HIV replication in patients and prevent progression to AIDS. However, it is not curative. Here we provide an overview of what antiretroviral drugs do and how the virus persists during therapy in rare reservoirs, such as latently infected CD4+ T cells. We also outline several innovative methods that are currently under development to eradicate HIV from infected individuals. These strategies include gene therapy approaches intended to create an HIV-resistant immune system, and activation/elimination approaches directed towards flushing out latent virus. This latter approach could involve the use of novel chemically synthesized analogs of natural activating agents.
Authors: Matthew D. Marsden, Jerome A. Zack
Institution: University of California, Los Angeles
Language: Estonian
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,880
Awards: Centers of Excellence for Influenza Research and Surveillance, G3121688723, Targeting HIV Reservoirs in vitro and in vivo, University of California, Los Angeles - to test nanoparticles for their ability to specifically activate HIV from latently infected cells, UCLA Center for AIDS Research (CFAR), Martin Delaney Collaboratory to Eradicate HIV-1 Infection
OpenAlex ID: W1992324754