Work

Immune checkpoint blockade in hepatocellular carcinoma: Current progress and future directions

Year: 2014

Type: article

Abstract: Immune checkpoint blockade has recently emerged as a promising therapeutic approach for various malignancies including hepatocellular carcinoma (HCC). Preclinical and clinical studies have shown the potential benefit of modulating the immunogenicity of HCC. In addition, recent advances in tumor immunology have broadened our understanding of the complex mechanism of immune evasion. In this review we summarize the current knowledge on HCC immunology and discuss the potential of immune checkpoint blockade as a novel HCC therapy from the basic, translational, and clinical perspectives.

Source: Hepatology

DOI: 10.1002/hep.27246

Authors: Tai Hato, Lipika Goyal, Tim F. Greten, Dan G. Duda, Andrew X. Zhu

Institutions: Massachusetts General Hospital, National Cancer Institute

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Cancer Society, National Institutes of Health, U.S. Food and Drug Administration, National Cancer Institute