Work

The L-type calcium channel in the heart: the beat goes on

Year: 2005

Type: review

Abstract: Sydney Ringer would be overwhelmed today by the implications of his simple experiment performed over 120 years ago showing that the heart would not beat in the absence of Ca2+. Fascination with the role of Ca2+ has proliferated into all aspects of our understanding of normal cardiac function and the progression of heart disease, including induction of cardiac hypertrophy, heart failure, and sudden death. This review examines the role of Ca2+ and the L-type voltage-dependent Ca2+ channels in cardiac disease.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci27167

Authors: I. Bodi, Gabor Mikala, Sheryl E Koch, Shahab A Akhter, Arnold Schwartz

Institution: University of Cincinnati

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,200