Mechanisms and Consequences of Injury and Repair in Older Organ Transplants
Year: 2014
Type: article
Abstract: Donor organ scarcity remains a significant clinical challenge in transplantation. Older organs, increasingly utilized to meet the growing demand for donor organs, have been linked to inferior transplant outcomes. Susceptibility to organ injury, reduced repair capacity, and increased immunogenicity are interrelated and impacted by physiological and pathological aging processes. Insights into the underlying mechanisms are needed to develop age-specific interventional strategies with regards to organ preservation, immunosuppression, and allocation. In this overview, we summarize current knowledge of injury and repair mechanisms and the effects of aging relevant to transplantation.
Source: Transplantation
Institutions: Brigham and Women's Hospital, Harvard University, Capital Medical University, University of Zurich, Beijing Chao-Yang Hospital, Capital Medical University, Erasmus MC, University Hospital Regensburg, University of Chicago, University Hospital Zurich, University of Regensburg, Leipzig University, IFB Adiposity Diseases
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1992502456