Work

Synthesis and monoamine transporter affinity of 2β-carbomethoxy-3β-(2″-, 3″- or 4″-substituted) biphenyltropanes

Year: 2000

Type: article

Abstract: A series of 11 novel 3beta-substituted biphenyltropanes was synthesized and evaluated by selective radioligand binding assays for affinity to monoamine transporters. Both 5-HTT potency and selectivity for 5-HTT over DAT was greatest with electron withdrawing group at the 3''-position.

Source: Bioorganic & Medicinal Chemistry Letters

DOI: 10.1016/s0960-894x(00)00317-6

Authors: Gilles Tamagnan, Ronald M Baldwin, Nora S Kula, Ross J Baldessarini, Robert B Innis

Institutions: Yale University, VA Connecticut Healthcare System, Harvard University, McLean Hospital, Massachusetts General Hospital

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,880