Work

Evidence against a protein in plasma that is a product of a factor XI mRNA splice variant missing exons 6 and 7

Year: 2010

Type: letter

Abstract: The disruption of the platform would likely interfere with binding to high-molecular-weight kininogen, 10 a protein that forms a complex with fXI in plasma.This, and the absence of fXI coagulant activity, 1 raise questions about the function of such a protein, if it was expressed.

Source: Blood

DOI: 10.1182/blood-2010-01-265702

Authors: David Gailani, Mao-fu Sun, Qiufang Cheng, Anton Matafonov, Erik I. Tucker, Andras Gruber, Jonas Emsley

Institutions: Vanderbilt University, Oregon Health & Science University, University of Nottingham

Language: English

Topic: Coagulation, Bradykinin, Polyphosphates, and Angioedema

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: British Heart Foundation

Award: Structure of coagulation factors from the intrinsic pathway: design and development of novel anticoagulants targeting the apple domain

OpenAlex ID: W1992661035

Cites: 11

Cited by: 4

Related to: 10