AgRP neurons: The foes of reproduction in leptin-deficient obese subjects
Year: 2012
Type: article
Abstract: Evolutionarily, the ability to regulate energy balance and reproduction in parallel is critical, because reproductive success will only occur when sufficient energy supplies are available. In periods when energy stores are depleted, reproduction is switched off in an attempt to save energy to optimize survival for subsequent reproductive success. The cellular mechanisms involved in the fine coordination of energy balance and reproduction are largely unknown. In PNAS, Wu et al. (1) shed light on a previously unsuspected neuronal population that appears to be fundamental for the coupling of energy deficit with impaired reproduction.
Authors: Marcelo O. Dietrich, Tamas L. Horvath
Institution: Yale University
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1992705588