Work

Asymmetric Oxidative Cation/Olefin Cyclization of Polyenes: Evidence for Reversible Cascade Cyclization

Year: 2008

Type: article

Abstract: Platinum and silver work together: Activation of [(xylyl-phanephos)PtCl2] by silver generates an electrophilic catalyst that can enantioselectively, diastereoselectively, and regioselectively promote the stereospecific oxidative cyclization of polyene-ols (see scheme; Tr=trityl). Mechanistic experiments indicate that the stereochemistry-determining step is not the initial cyclization step, but rather a subsequent step in the reaction.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200801423

Authors: Charles A. Mullen, Alison N. Campbell, Michel R. Gagné

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: A New Approach To Selective Noble Metal Catalysts