Work

Conformation of sarafotoxin‐6b in aqueous solution determined by NMR spectroscopy and distance geometry

Year: 1991

Type: article

Abstract: The solution structure of sarafotoxin-6b in water has been determined using high-resolution NMR spectroscopy. 127 proton-proton distance measurements and three phi dihedral angle constraints derived from NMR spectra were used to calculate the solution structure using a combination of distance geometry and restrained molecular dynamics. The major structural feature of the resulting family of five structures was a right-handed alpha-helix extending from K9 to Q17. In contrast, the C-terminal region of the peptide appears not to adopt a preferred conformation in aqueous solution. The present structure is compared with those previously determined for endothelin peptides in non-aqueous solvents.

Source: FEBS Letters

DOI: 10.1016/0014-5793(91)80488-o

Authors: Robyn G. Mills, Annette R. Atkins, Tim Harvey, F.Keith Junius, Ross Smith, Glenn F. King

Institutions: The University of Sydney, The University of Queensland, University of Oxford

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W1992746938

FWCI: 2.114

Cites: 13

Cited by: 33

Related to: 10