Rapid Generation Of Antigen-Specific T Cells for Pre-Clinical And Clinical Applications Using A Novel Mini Cell Bioreactor
Year: 2009
Type: article
Abstract: The production of antigen-specific T cells for the reconstitution of tumor or pathogen-specific immunity after HSCT is limited by the time taken to produce large T cell numbers, while retaining function and specificity. The requirements for expansion of antigen-driven cytotoxic T lymphocytes (CTLs) are rigorous, and in some cases only possible in 2 cm2 wells. Conventional cell growth is limited by gas exchange, nutrients and waste build-up. Bioreactors developed to solve these problems tend to be complex and expensive and not always conducive to antigen-specific T cell growth.
Authors: L. Brenner, A.M. Leen, J. Wilson, H.E. Heslop, G. Dotti, C.M. Rooney, J.F. Vera
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W1992817234