Year: 2013
Type: article
Abstract: A tumor gains its selective advantage from ‘driver’ mutations in genes involved in key pathways regulating cell identity, survival and genome stability. However, tumorigenic processes are mutagenic, and there may be many more mutated ‘passenger’ genes that confer no further advantage to the cell and expose the tumor to immune surveillance by the body. Some genes are recurrently mutated, whereas others are rarely mutated. The Pan-Cancer analysis group used comparisons across tumor types to refine its ability to discriminate driver mutations, enabling the improved delineation of the pathways through which driver mutations exert their effects on tumor initiation, proliferation and spread.
Source: Nature Genetics
DOI: 10.1038/ng.2786
Authors: Abel Gonzalez-Perez, David Tamborero, Nuria Lopez-Bigas, Adam Margolin, Li Ding, Dmitry Gordenin, Myles Axton
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $12,690
OpenAlex ID: W1992887987