Multimodal Quantitative Magnetic Resonance Imaging of Thalamic Development and Aging across the Human Lifespan: Implications to Neurodegeneration in Multiple Sclerosis
Year: 2011
Type: article
Study design: Observational Study
Abstract: The human brain thalami play essential roles in integrating cognitive, sensory, and motor functions. In multiple sclerosis (MS), quantitative magnetic resonance imaging (qMRI) measurements of the thalami provide important biomarkers of disease progression, but late development and aging confound the interpretation of data collected from patients over a wide age range. Thalamic tissue volume loss due to natural aging and its interplay with lesion-driven pathology has not been investigated previously. In this work, we used standardized thalamic volumetry combined with diffusion tensor imaging, T2 relaxometry, and lesion mapping on large cohorts of controls (N = 255, age range = 6.2-69.1 years) and MS patients (N = 109, age range = 20.8-68.5 years) to demonstrate early age- and lesion-independent thalamic neurodegeneration.
Source: Journal of Neuroscience
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: Developmental Phonological Dyslexia: Neural Mechanisms, G2171953999, Tramatic Stress After Pediatric Injury: Neurobiological Influences, Automated MR Image Analysis in MS: Identification of a Surrogate, G4474647205, Diffusion Tensor Imaging of Wallerian Degeneration in MS, G7678675143, 3 T Whole Body Magnetic Resonance Scanner, G8873196344
OpenAlex ID: W1992936223