Mechanisms and Regulation of the Gene-Expression Response to Sepsis
Year: 2010
Type: review
Abstract: Sepsis is defined as the systemic inflammatory response of the human host that is triggered by an invading pathogen. Despite tremendous advances in both our knowledge of and treatment strategies for this syndrome, sepsis remains among the major causes of morbidity and mortality in children worldwide. Thus, we hypothesize that an improved mechanistic understanding obtained via basic and translational science will continue to identify novel therapeutic targets and approaches. As a result, given the central importance of the alterations in gene expression in regulating the human host's physiologic response to a pathogen, we review the complex factors-genetics, transcriptional expression, and epigenetics-that regulate unique gene-expression patterns in pediatric sepsis and septic shock. We anticipate that emerging data from genetic, genomic, and other translation studies in pediatric sepsis will advance our biological understanding of this response and undoubtedly identify targets for newer therapies.
Source: PEDIATRICS
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: PP2A Regulation of the JNK MAPK Pathway, G1572469352, Genomic analysis of pediatric SIRS and septic shock, G239052087, G2931825077, G324188356, G4169322547, THE PEDIATRIC SEPSIS BIOMARKER RISK MODEL, Michigan Institute for Clinical and Health Research (MICHR) (UL1), Effects of glycemic control on immunity, The Host Response to Calfactant for Direct Acute Lung Injury in Critically Ill Ch, Pediatric Critical Care and Trauma Scientist Development Program (PCCTSDP)
OpenAlex ID: W1992951503