Work

Rhythmogenic effects of weak electrotonic coupling in neuronal models.

Year: 1992

Type: article

Abstract: Strong gap-junctional coupling can synchronize the electrical oscillations of cells, but we show, in a theoretical model, that weak coupling can phase lock two cells 180 degrees out-of-phase. Antiphase oscillations can exist in parameter regimens where in-phase oscillations break down. Some consequences are (i) coupling two excitable cells leads to pacemaking, (ii) coupling two pacemaker cells leads to bursting, and (iii) coupling two bursters increases burst period. The latter shows that details of the fast spikes can affect macroscopic properties of the slow bursts. These effects hold in other models for bursting and may play a role in the collective behavior of cellular ensembles.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.89.6.2471

Authors: A Sherman, J Rinzel

Institutions: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Language: English

Topic: Neural dynamics and brain function

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funder: National Institutes of Health

OpenAlex ID: W1992962897

FWCI: 3.62

Cites: 17

Cited by: 288

Related to: 10