Work

Roadblocks to success for RNA CARs in solid tumors

Year: 2014

Type: article

Abstract: While CAR therapy has begun to demonstrate efficacy, cell-engineering techniques that result in permanent genomic modification carry several safety concerns. CAR expression driven by RNA creates a platform for delivery of highly-active cell therapy while avoiding long-term CAR-driven toxicity. Using models of pediatric neuroblastoma, we have found that RNA CAR T cell activity is limited by ineffective tumor infiltration.

Source: OncoImmunology

DOI: 10.4161/21624011.2014.962974

Authors: Nathan Singh, David M Barrett, Stephan A Grupp

Institutions: University of Pennsylvania, Children's Hospital of Philadelphia

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913