Work

A Selenide-Based Approach to Photochemical Cleavage of Peptide and Protein Backbones at Engineered Backbone Esters

Year: 2009

Type: article

Abstract: A strategy for photochemical cleavage of peptide and protein backbones is described, which is based on a selenide-mediated cleavage of a backbone ester moiety. Studies in model systems establish the viability of the chemistry and suggest the method could be a valuable tool for chemical biology studies of proteins.

Source: The Journal of Organic Chemistry

DOI: 10.1021/jo901368g

Authors: Amy L. Eastwood, Angela P. Blum, Niki M. Zacharias, Dennis A. Dougherty

Institution: California Institute of Technology

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke

Awards: G239511019, PREDOCTORAL TRAINING IN BIOLOGY AND CHEMISTRY, Probing Receptor Structures with Unnatural Amino Acids, Probing Receptor Structures with Unnatural Amino Acids