Work

Human trophoblast cell-surface antigens defined by monoclonal antibodies.

Year: 1981

Type: article

Abstract: A series of monoclonal antibodies has been raised against the human choriocarcinoma cell-line, BeWo. Four antigens, Trop-1, -2, -3, and -4, are defined on normal and malignant trophoblast cells. Trop-1 and Trop-2 appear to be specifically expressed on syncytio- and cytotrophoblasts, whereas Trop-3 and Trop-4 are also detected on various tumor cell lines, normal lymphocytes, and monocytes. Anti-Trop-1 and anti-Trop-2 antibodies might prove useful for detection and isolation of fetal trophoblast cells circulating in pregnant women's blood and for diagnosis and therapy in patients having choriocarcinomas and other germ-cell neoplasms.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.78.8.5147

Authors: M Lipinski, D R Parks, R V Rouse, L A Herzenberg

Institutions: Stanford Medicine, Stanford University

Language: English

Topic: Gestational Trophoblastic Disease Studies

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Cancer Society, National Institutes of Health