Year: 2013
Type: article
Abstract: and presented a thesis in 1962 entitled "Transfer and Distribution of Urea in the Body".Part of this study was on the movement of urea into the brain [1].This aspect of his early research was to dominate the rest of his scientific career and subsequent research into the regulation of the brain fluid environment and the transport of drugs, ions and other solutes across the brain microvasculature which forms the major component of the blood-brain barrier.After Oxford, Mike returned to London to a post of Research Assistant, supported by the Medical Research Council, in the Department of Physiology at University College, where he worked with, and was highly influenced by, Hugh Davson [2].Hugh was a pioneering figure in blood-brain barrier and cerebrospinal fluid research.Together they used the technique of ventriculo-cisternal perfusion adapted from the original method of Pappenheimer et al. [3] to quantify the transport of various substances into and out of the cerebrospinal fluid.This method is still in use today.In 1965 he moved to Los Angeles, California, as Assistant Professor of
Source: Fluids and Barriers of the CNS
Authors: David J Begley, Hazel C Jones
Institution: King's College London
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,390
OpenAlex ID: W1993216812