Genomic Comparison of cag Pathogenicity Island (PAI)-Positive and -Negative Helicobacter pylori Strains: Identification of Novel Markers for cag PAI-Positive Strains
Year: 2005
Type: article
Abstract: In an analysis of Helicobacter pylori genomic DNA by macroarray methodology, genomic DNA from a panel of cag pathogenicity island (PAI)-negative H. pylori clinical isolates failed to hybridize with 27 genes located outside the cag PAI in a cag PAI-positive reference strain. PCR analyses confirmed that HP0217 (encoding a lipopolysaccharide biosynthetic protein) and HP1079 (encoding a protein of unknown function) were present significantly more frequently in cagA-positive strains than in cagA-negative strains. A low G+C content of these two genes suggests they were acquired by horizontal transfer events.
Source: Infection and Immunity
Institutions: William & Mary, Vanderbilt University, Nashville VA Medical Center
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: H. Pylory factors associated with peptic ulcer disease, H PYLORI RELATIONSHIP TO DIGESTIVE DISEASES AND CANCER, Helicobacter Pylori and Gastrointestinal Biology, Evolution of a bacterial genome encoding increased virulence: the genomics of Hel, H. Pylori Relationship to Digestive Diseases and Cancer
OpenAlex ID: W1993232252