Work

Molecular Basis of Insulin-stimulated GLUT4 Vesicle Trafficking

Year: 1999

Type: review

Abstract: Among all the diverse actions of insulin, one of the most critical and intensively studied is its regulation of glucose homeostasis. In the postabsorptive state, insulin action in muscle and adipose tissue results in increased glucose uptake from the circulation, thereby maintaining plasma euglycemia and preventing hyperglycemia (1-3). Defects in this pathway result in insulin resistance, a condition in which excessive concentrations of insulin are required to reduce blood glucose levels and often precede the development of frank Type II diabetes (3, 4).

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.274.5.2593

Authors: Jeffrey E. Pessin, Debbie C. Thurmond, Jeffrey S. Elmendorf, Kenneth J. Coker, Shuichi Okada

Institution: University of Iowa

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430