Work

Pathophysiology of the catastrophic antiphospholipid syndrome (CAPS)

Year: 2000

Type: review

Abstract: Antiphospholipid antibodies (APA) are a common cause of acquired thrombophilia. APA recognize plasma phospholipid-binding proteins (e. g., beta(2)-glycoprotein I, prothrombin, annexin V, etc.). Catastrophic antiphospholipid syndrome (CAPS) is an uncommon variant of the antiphospholipid syndrome. CAPS patients often present with multiorgan failure. Precipitating factors include surgical procedures, drugs, and discontinuation of anticoagulant therapy. Increasingly, infections are recognized as a major precipitating condition. The majority of patients present with renal involvement as well as evidence of acute respiratory distress syndrome (ARDS). This review discusses the clinical and pathophysiologic aspects of CAPS as well as the differenital diagnosis.

Source: American Journal of Hematology

DOI: 10.1002/1096-8652(200010)65:2<154::aid-ajh11>3.0.co;2-a

Authors: Douglas A. Triplett, Ronald A. Asherson

Institutions: Ball Memorial Hospital, University of Cape Town, Groote Schuur Hospital

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1993309117

FWCI: 1.404

Cites: 51

Cited by: 57

Related to: 10