Work

Integrated optical- and acoustic-resolution photoacoustic microscopy based on an optical fiber bundle

Year: 2012

Type: article

Abstract: Photoacoustic microscopy (PAM), whose spatial resolution and maximum imaging depth are both scalable, has made great progress in recent years. However, each PAM system currently achieves only one resolution with an associated maximum imaging depth. Here, we present an integrated optical-resolution (OR) and acoustic-resolution (AR) PAM system implemented by delivering light via an optical fiber bundle. A single fiber core is used to deliver light for OR illumination in order to achieve a small spot size and hence high lateral resolution, whereas all the fiber cores are used to deliver more energy for AR illumination. Most other components are shared by the OR and AR imaging. The lateral resolution can be seamlessly switched between 2.2 and 40 μm as the maximum imaging depth is switched between 1.3 and 3.0 mm. The system enables automatically coregistered higher-resolution OR and deeper AR photoacoustic imaging.

Source: Optics Letters

DOI: 10.1364/ol.38.000052

Authors: Wenxin Xing, Lidai Wang, Konstantin Maslov, Lihong V. Wang

Institution: Washington University in St. Louis

Language: English

Topic: Photoacoustic and Ultrasonic Imaging

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze

Funders: National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering