Year: 2000
Type: article
Abstract: Most neurodegenerative diseases, such as Alzheimer's disease, amyotrophic lateral sclerosis (ALS), lipid storage diseases, and leukodystrophies, globally affect the nervous system and involve many types of cells. Thus, the application of gene therapy in a global manner to these diseases raises the problem of how to distribute a gene therapy vector to the nervous system. In contrast, Parkinson's disease is confined primarily to a well-defined, compact group of neurons. This fact, along with the availability of well-defined animal models, has helped bring Parkinson's disease to the forefront in studies of gene therapy for neurodegenerative diseases.
Source: Molecular Therapy
Author: Martha C. Bohn
Institution: Northwestern University
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W1993629435