Year: 2011
Type: article
Abstract: BACKGROUND: Observational studies and randomized trials have suggested that estrogens and/or progesterone may lower the risk for colorectal cancer. Inherited variation in the sex-hormone genes may be one mechanism by which sex hormones affect colorectal cancer, although data are limited. METHOD: We conducted a comprehensive evaluation of single nucleotide polymorphisms (SNPs) in genes encoding 3 hormone receptors (ESR1, ESR2, PGR) and 5 hormone synthesizers (CYP19A1 and CYP17A1, HSD17B1, HSD17B2, HSD17B4) among 427 women with incident colorectal cancer and 871 matched controls who were Caucasians of European ancestry from 93676 postmenopausal women enrolled in the Women's Health Initiative Observational cohort. A total of 242 haplotype-tagging and functional SNPs in the 8 genes were included for analysis. Unconditional logistic regression with adjustment for age and hysterectomy status was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: We observed a weak association between the CYP17A1 rs17724534 SNP and colorectal cancer risk (OR per risk allele (A) = 1.39, 95% CI = 1.09-1.78, corrected p-value = 0.07). In addition, a suggestive interaction between rs17724534 and rs10883782 in 2 discrete LD blocks of CYP17A1 was observed in relation to colorectal cancer (empirical p value = 0.04). Moreover, one haplotype block of CYP19A1 was associated with colorectal cancer (corrected global p value = 0.02), which likely reflected the association with the tagging SNP, rs1902584, in the block. CONCLUSION: Our findings offer some support for a suggestive association of CYP17A1 and CYP19A1 variants with colorectal cancer risk.
Source: BMC Medical Genetics
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,380
Funders: U.S. Department of Health and Human Services, Brigham and Women's Hospital, Kaiser Permanente, Brown University, University of Miami, Wayne State University, Ohio State University, Emory University, Northwestern University, George Washington University, Wake Forest University, University of Minnesota, University of Pittsburgh, University of Cincinnati, University of Nevada, Reno, National Institutes of Health, Health Science Center, University of Tennessee, University of North Carolina at Chapel Hill, University at Buffalo, National Heart, Lung, and Blood Institute, National Cancer Institute
Awards: CLIN CTR FOR THE CLIN TRIAL & OBSERVATIONAL STUDY OF WHI, G109231058, G1107292973, Women's Health Initiative, Women's Health Initiative, Women's Health Initiative, G1286168924, Women's Health Initiative, Women's Health Initiative, CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI, G1512276389, Women's Health Initiative, G152626716, G156924709, Women's Health Initiative, G1593340546, G1617453120, G1623571357, G1646017446, Women's Health Initiative, Women's Health Initiative, G181468914, Women's Health Initiative, G206718646, G211028185, CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI, Women's Health Initiative, G2182082016, G2253702613, G2286437695, G2295046671, G2417273319, CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI, G2547046739, G257474614, Estrogen and Progesterone-related Gene Variants and Colorectal Cancer Risk, Women's Health Initiative, G2768409618, G2852769941, G2880260212, G300426088, G3053443584, G306350359, G3290335435, Women's Health Initiative, G3337978133, Women's Health Initiative Memory Study (WHIMS), G3404453056, G3544793024, Women's Health Initiative, G3642616392, G3658685098, G3696348274, G3916577102, Women's Health Initiative, G4002295999, Women's Health Initiative, Women's Health Initiative, G413560588, G4214622172, G4216744017, G4281851297, COORDINATING CENTER FOR WOMEN'S HEALTH INITIATIVE, G429396632, G4321061599, G4355687608, G445374210, G4454202622, Women's Health Initiative, G4560602636, Women's Health Initiative, G484043965, Women's Health Initiative, Women's Health Initiative, G4940723635, G5183277930, G5238945333, FOR ALL FIELD CENTER FOR WHI EXTENSION, G530368906, Women's Health Initiative, G532295152, G5415877130, Women's Health Initiative, G555506801, G5611709376, Women's Health Initiative, G5959015892, G5965015984, G603760282, G6424558485, G6464247198, G6522987136, G6670851527, G6730395537, Women's Health Initiative, Women's Health Initiative, Women's Health Initiative, G6893458194, Women's Health Initiative, Sex steroid hormones, gene variants, and colorectal cancer, G7066869570, G7071300326, G7223985928, G725251684, G7272550893, Women's Health Initiative, G7323080267, G7422186829, Women's Health Initiative, CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI, G7572166205, G7582705761, G7739768352, Women's Health Initiative, CLINICAL CENTER FOR THE CLINICAL TRIAL & OBSERVATIONAL STUDY OF WHI, G8226798419, G857724489, G8606667874, G8780700017, G8898275213, G8913509553, G8934942062, Women's Health Initiative, G985928507, G999174792
OpenAlex ID: W1993716251