Work

Duplication-targeted DNA methylation and mutagenesis in the evolution of eukaryotic chromosomes.

Year: 1992

Type: article

Abstract: Mammalian genomes are threatened with gene inactivation and chromosomal scrambling by recombination between repeated sequences such as mobile genetic elements and pseudogenes. We present and test a model for a defensive strategy based on the methylation and subsequent mutation of CpG dinucleotides in those DNA duplications that create uninterrupted homologous sequences longer than about 0.3 kilobases. The model helps to explain both the diversity of CpG frequencies in different genes and the persistence of gene fragmentation into exons and introns.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.89.3.1075

Authors: M C Kricker, J W Drake, M Radman

Institutions: National Institutes of Health, National Institute of Environmental Health Sciences

Language: English

Topic: Chromosomal and Genetic Variations

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W1993716324

FWCI: 23.1

Cites: 33

Cited by: 145

Related to: 10