Work

NH-1,2,3-Triazole Inhibitors of the VIM-2 Metallo-β-Lactamase

Year: 2010

Type: article

Abstract: Metallo-ß-lactamases (MBL) are an emerging cause of bacterial resistance to antibiotic treatment. The VIM-2 ß-lactamase is the most commonly encountered MBL in clinical isolates worldwide. Described here are potent and selective small molecule inhibitors of VIM-2 containing the arylsulfonyl-NH-1,2,3-triazole chemotype that potentiate the efficacy of the ß-lactam, imipenem, in E. coli.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/ml900022q

Authors: Timo Weide, S. Adrian Saldanha, Dmitriy Minond, Timothy P. Spicer, Joseph R. Fotsing, Michael Spaargaren, Jean-Marie Frère, Carine Bebrone, K. Barry Sharpless, Peter S. Hodder, Valery V. Fokin

Institutions: Scripps Research Institute, University of Liège

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke

Awards: Carbon-Heteroatom Bond-Forming Reactions, HTS assays for discovery of novel beta-lactamase inhibitors via click chemistry

OpenAlex ID: W1993796398

FWCI: 1.937

Cites: 10

Cited by: 87

Related to: 10