Work

Filamin A

Year: 2012

Type: article

Abstract: Filamins are a family of actin-binding proteins composed of filamin A, B and C. Besides of their ability to induce perpendicular branching of F-actin filaments via their actin binding domains near the N-terminus, filamins can regulate multiple cellular functions because of their unique ability to recruit more than 90 protein binding partners to their primary sequences which are having highly diversified cellular functions. However, this family of proteins has not been examined in the testis until recently. Herein, we highlight recent findings in the field regarding the role of these proteins in cell epithelia, and based on recent data in the testis regarding their role on spermatogenesis, this review provides the basis for future functional studies.

Source: Spermatogenesis

DOI: 10.4161/spmg.20223

Authors: Wenhui Su, Dolores D. Mruk, C. Yan Cheng

Institutions: Population Council, China Medical University, Population Council, China Medical University

Language: English

Topic: Sperm and Testicular Function

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Funders: National Natural Science Foundation of China, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Biology of the Blood-Testis Barrier, Cooperative Contraceptive Research Center: New Contraceptives with Dual Benefits, G9000101805, G9000287097