Work

Isostructural Self-Assembly of 2′-Deoxyguanosine Derivatives in Aqueous and Organic Media

Year: 2008

Type: article

Abstract: We report the self-assembly of a hydrophilic 8-(m-acetylphenyl)-2'-deoxyguanosine (mAG) derivative into a discrete and thermally stable hexadecameric supramolecule in aqueous media. We demonstrate that this hexadecamer is isostructural to the one formed by a related lipophilic derivative in organic media. This mAG moiety represents a rare example of a small-molecule recognition motif that is capable of assembling isostructurally and with high fidelity in both organic and aqueous media.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja8039019

Authors: Marilyn García-Arriaga, Gerard Hobley, José M. Rivera

Institutions: University of Puerto Rico at Río Piedras, University of Puerto Rico System

Language: English

Topic: Supramolecular Self-Assembly in Materials

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: National Science Foundation, National Institutes of Health, National Institute of General Medical Sciences, Office of Experimental Program to Stimulate Competitive Research