Morphogenesis in sea urchin embryos: linking cellular events to gene regulatory network states
Year: 2011
Type: review
Abstract: Gastrulation in the sea urchin begins with ingression of the primary mesenchyme cells (PMCs) at the vegetal pole of the embryo. After entering the blastocoel the PMCs migrate, form a syncitium, and synthesize the skeleton of the embryo. Several hours after the PMCs ingress the vegetal plate buckles to initiate invagination of the archenteron. That morphogenetic process occurs in several steps. The nonskeletogenic cells produce the initial inbending of the vegetal plate. Endoderm cells then rearrange and extend the length of the gut across the blastocoel to a target near the animal pole. Finally, cells that will form part of the midgut and hindgut are added to complete gastrulation. Later, the stomodeum invaginates from the oral ectoderm and fuses with the foregut to complete the archenteron. In advance of, and during these morphogenetic events, an increasingly complex input of transcription factors controls the specification and the cell biological events that conduct the gastrulation movements. WIREs Dev Biol 2012, 1:231–252. doi: 10.1002/wdev.18 This article is categorized under: Gene Expression and Transcriptional Hierarchies > Gene Networks and Genomics Early Embryonic Development > Gastrulation and Neurulation Comparative Development and Evolution > Model Systems
DOI: 10.1002/wdev.18
Institution: Duke University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1993979230