Work

618. Hydrodynamic Limb Vein-Delivered Xenogeneic Plasmid DNA Cancer Vaccine Effectively Induces Antitumor Protection

Year: 2006

Type: article

Abstract: We recently developed a clinically relevant approach for intravascular hydrodynamic limb vein (HLV) delivery of nucleic acids that results in high-level transgene expression in myofibers. This novel delivery method is a very effective means to induce a high-titer antibody response against expressed transgene antigens following genetic immunization. Here, we examine the utility of HLV as a method to deliver a genetic cancer vaccine in mice.

Source: Molecular Therapy

DOI: 10.1016/j.ymthe.2006.08.693

Authors: Zane C. Neal, Mary Kay Bates, Hans Herweijer

Institution: Mirus Bio (United States)

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500