Work

Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11

Year: 1985

Type: article

Abstract: We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the C lambda and some V lambda sequences translocate to the 8q+ chromosome whereas some V lambda sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that V lambda is proximal to C lambda.

Source: Nucleic Acids Research

DOI: 10.1093/nar/13.2.381

Authors: B.S. Emanuel, L.A. Cannizzaro, I. Magrath, Y. Tsujimoto, P.C. Nowell, C.M. Croce

Institutions: University of Pennsylvania, National Cancer Institute, The Wistar Institute

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: University of Pennsylvania, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences