Work

Likelihood-enhanced fast translation functions

Year: 2005

Type: article

Abstract: This paper is a companion to a recent paper on fast rotation functions [Storoni et al. (2004), Acta Cryst. D60, 432-438], which showed how a Taylor-series expansion of the maximum-likelihood rotation function leads to improved likelihood-enhanced fast rotation functions. In a similar manner, it is shown here how linear and quadratic Taylor-series expansions and least-squares approximations of the maximum-likelihood translation function lead to likelihood-enhanced translation functions, which can be calculated by FFT and which are more sensitive to the correct translation than the traditional correlation-coefficient fast translation function. These likelihood-enhanced translation targets for molecular-replacement searches have been implemented in the program Phaser using the Computational Crystallography Toolbox (cctbx).

Source: Acta Crystallographica Section D Biological Crystallography

DOI: 10.1107/s0907444905001617

Authors: Airlie J. McCoy, Ralf W. Grosse-Kunstleve, Laurent C. Storoni, Randy J. Read

Institutions: University of Cambridge, Wellcome Trust, Lawrence Berkeley National Laboratory

Language: English

Topic: Enzyme Structure and Function

Subfield: Structural Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,740

Funders: Wellcome Trust, National Institutes of Health, National Institute of General Medical Sciences